Search results for " Pediatric Patients"

showing 6 items of 6 documents

Cognate HLA absence in trans diminishes human NK cell education

2016

NK cells are innate lymphocytes with protective functions against viral infections and tumor formation. Human NK cells carry inhibitory killer cell Ig-like receptors (KIRs), which recognize distinct HLAs. NK cells with KIRs for self-HLA molecules acquire superior cytotoxicity against HLA– tumor cells during education for improved missing-self recognition. Here, we reconstituted mice with human hematopoietic cells from donors with homozygous KIR ligands or with a mix of hematopoietic cells from these homozygous donors, allowing assessment of the resulting KIR repertoire and NK cell education. We found that co-reconstitution with 2 KIR ligand–mismatched compartments did not alter the frequenc…

0301 basic medicine10028 Institute of Medical VirologyEpstein-Barr Virus InfectionsHerpesvirus 4 HumanCellchemical and pharmacologic phenomena610 Medicine & healthMice SCIDHuman leukocyte antigen2700 General MedicineAdaptive ImmunityBiology10263 Institute of Experimental Immunology03 medical and health sciencesMice Inbred NOD10049 Institute of Pathology and Molecular PathologymedicineAnimalsHumansCytotoxicityReceptorHistocompatibility Antigens Class IHEK 293 cellsGeneral MedicineAcquired immune systemKiller Cells NaturalHaematopoiesisHEK293 Cells030104 developmental biologymedicine.anatomical_structureNatural-Killer-Cells Cord Blood Transplantation Cytomegalovirus-Infection Class-I Inhibitory receptors Pediatric Patients TumorsImmunologyK562 CellsResearch ArticleK562 cells
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Therapeutic Effectiveness of Nutrition Therapy in Pediatric Patients with Chronic Liver Diseases Awaiting Liver Transplantation

2013

It is important to prevent protein/calorie malnutrition in children with end stage liver diseases prior to transplantation. This study involved 34 patients between the ages of 10 and 156 months (mean value 25.69 months ± 32.2) (13 females and 21 males) on the liver transplant waiting list. Data collected as of three months before transplant and up to ten months after the procedure concerned gender, age, weight, height, Pediatric End Stage Liver Disease Score, baseline pathology, type of nutrition, type of transplant, immunosuppression, pulse steroid therapy, length of stay, and post transplant complications. Linear regression analysis showed that the length of hospital stay was 24.5 days mo…

medicine.medical_specialtyCaloriebusiness.industrymedicine.medical_treatmentImmunosuppressionTransplant Waiting ListLiver transplantationmedicine.diseaseSettore BIO/09 - Fisiologianutrition therapy pediatric patients liver transplantationSurgeryTransplantationMalnutritionInternal medicinemedicinePopulation studyMedical nutrition therapybusinessJournal of Food Research
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Intraoperative monitoring of cerebral blood flow during ventricular shunting in hydrocephalic pediatric patients.

1995

Several studies have demonstrated lowered cerebral blood flow (CBF) in patients with hydrocephalus and symptoms of raised intracranial pressure. Ventricular shunting in such cases permits a sudden increase in CBF. The pathophysiology of functional brain deficit secondary to hydrocephalus is little understood. Improvement of the patient's clinical status after drainage of CSF suggests that cerebral dysfunction is not necessarily due to permanent brain damage. In fact, it improves rapidly after ventricular taps. In view of this it would be helpful to monitor cerebral perfusion. The transcranial Doppler (TCD) ultrasonography technique allows real-time monitoring of the intracranial circulation…

MaleIntracranial PressureUltrasonography Doppler TranscranialVentriculoperitoneal ShuntPostoperative ComplicationsCerebrospinal Fluid PressureMonitoring Intraoperativemedicine.arterymedicineHumansCerebral perfusion pressureChildTranscranial doppler Hydrocephalus pediatric patientsbusiness.industrySettore MED/27 - NeurochirurgiaBrainInfantGeneral Medicinemedicine.diseaseHydrocephalusTranscranial DopplerShuntingmedicine.anatomical_structureCerebral blood flowVentricleAnesthesiaPediatrics Perinatology and Child HealthMiddle cerebral arteryCerebral ventriclecardiovascular systemFemaleNeurology (clinical)businessBlood Flow VelocityHydrocephalus
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The old and new tests for celiac disease: which is the best test combination to diagnose celiac disease in pediatric patients?

2011

BACKGROUND In the diagnosis of celiac disease (CD), serum assays for anti-endomysium (EMA) and anti-transglutaminase (anti-tTG) antibodies have excellent diagnostic accuracy. However, these assays are less sensitive in young pediatric patients. Recently, a new ELISA test using deamidated gliadin peptides (DGP) as antigen has proved to be very sensitive and specific even in pediatric patients. In addition, anti-actin IgA antibodies (AAA) is another test that can be used in CD patients because antibody concentrations correlate with the degree of villous atrophy. This study evaluated the clinical accuracy of anti-tTG, EMA, AGA, anti-DGP and AAA and the effectiveness of these in different combi…

Malemedicine.medical_specialtySettore MED/09 - Medicina InternaTissue transglutaminaseClinical BiochemistryFluorescent Antibody TechniqueDiagnostic accuracyEnzyme-Linked Immunosorbent AssayDiseaseGastroenterologySensitivity and SpecificityAntigenInternal medicinemedicineHumansceliac disease; diagnostic test; pediatric patientspediatric patientsbiologybusiness.industryClinical Laboratory TechniquesBiochemistry (medical)InfantGeneral MedicineReference StandardsEndomysiummedicine.anatomical_structurediagnostic testCase-Control StudiesChild PreschoolElisa testbiology.proteinFemaleAntibodyGliadinbusinessceliac disease
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Syncope in pediatric patients: role of arrhythmias

2009

AdultAdolescentIncidenceInfant NewbornInfantArrhythmias CardiacSyncopeLong QT SyndromeChild PreschoolSyncope pediatric patientsTachycardia SupraventricularHumansAtrioventricular BlockChildSicilyRetrospective Studies
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Teratoma with a malignant somatic component in pediatric patients: The Associazione Italiana Ematologia Oncologia Pediatrica (AIEOP) experience

2010

BACKGROUND: Teratoma with a malignant somatic component (TMSC) is rare but described in adults, whereas information on pediatric presentation is sparse. PROCEDURE: The Associazione Italiana Ematologia Oncologia Pediatrica identified 14 cases of TMSC. Clinical files and pathology specimens were reviewed. RESULTS: The series (9 female, 5 male) showed the following disease: testis (2), sacrococcygeal (3), ovary (3), retroperitoneum (3), mediastinum (2), and foot soft tissue (1). Distribution of the somatic component was: carcinoma (4), pancreatic neuroendocrine tumor (1), neuroblastoma (3), rhabdomyosarcoma (3), rhabdomyosarcoma plus liposarcoma, chondrosarcoma, neurogenic sarcoma (1), chondro…

Malepediatric patientsAdolescentTeratoma; pediatric patientsSettore MED/20 - Chirurgia Pediatrica E InfantileInfant NewbornTeratomaInfantgerm cell tumorPrognosisSettore MED/38 - Pediatria Generale E SpecialisticaTreatment OutcomeItalyChild PreschoolSettore MED/20Humansmalignant trasformationFemaleChildchildhoodNeoplasm StagingRetrospective Studies
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